5,7-Dichloro-1H-pyrrolo[2,3-c]pyridine

5,7-Dichloro-1H-pyrrolo[2,3-c]pyridine - Names and Identifiers

Name	5,7-Dichloro-1H-pyrrolo[2,3-c]pyridine
Synonyms	138235 5,7-Dichloro-6-azaindole 5,7-DICHLORO-6-AZAINDOLE 5,7-dichloro-1H-pyrrolo[2,3-c]pyridine 5,7-Dichloro-1H-pyrrolo[2,3-c]pyridine 1H-Pyrrolo[2,3-c]pyridine, 5,7-dichloro-
CAS	1001412-41-4
EINECS	200-258-5
InChI	InChI=1S/C7H4Cl2N2/c8-5-3-4-1-2-10-6(4)7(9)11-5/h1-3,10H

5,7-Dichloro-1H-pyrrolo[2,3-c]pyridine - Physico-chemical Properties

Molecular Formula	C7H4Cl2N2
Molar Mass	187.03
Density	1.571
Boling Point	371.6±37.0 °C(Predicted)
pKa	12.16±0.40(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C

5,7-Dichloro-1H-pyrrolo[2,3-c]pyridine - Introduction

Nature:
5,7-Dichloro-1H-pyrrolo [2,3-c] pyridine is a colorless to pale yellow solid, soluble in organic solvents, insoluble in water. It has a melting point of 210-215°C and a boiling point of about 380°C.

Use:
5,7-Dichloro-1H-pyrrolo [2,3-c] pyridine has a wide range of applications in the field of organic synthesis. It is an effective sulfur dichloride deprotection reagent and can be used to remove protecting groups in alcohols, phenols or ethers. In addition, it can also be used as a nitrogen source in organic synthesis, a carbon source, a synthetic reagent for aromatic compounds, etc.

Preparation Method:
5,7-Dichloro-1H-pyrrolo [2,3-c] pyridine is generally synthesized by chlorination of pyrrolo [2,3-c] pyrrole. First, pyrrolo [2,3-c] pyrrole is reacted with thionyl chloride in a suitable solvent, followed by hydrogenation under basic conditions to obtain the target product.

Safety Information:
5,7-Dichloro-1H-pyrrolo [2,3-c] pyridine may be harmful to humans under certain conditions. It may be irritating to the skin, eyes and respiratory system. Wear appropriate personal protective equipment during use or operation to prevent contact and inhalation. At the same time, it should be ensured that the operation is carried out in a well-ventilated place. In case of accidental contact, rinse immediately with plenty of water and seek medical help.

Last Update：2024-04-09 21:11:58